Apurinic/apyrimidinic (AP) sites are the most common DNA lesions, which benefit from a
most efficient repair by the base excision pathway. The impact of losing a nucleobase on the …

Apurinic/apyrimidinic sites are the most common forms of DNA damage under physiological
conditions, yet their structural and dynamical behavior within nucleosome core particles has …

DNA is tightly wrapped around histone proteins in nucleosome core particles (NCPs) yet
must become accessible for processing in the cell. This accessibility, a key component of …

Clustered apurinic/apyrimidinic (AP; abasic) DNA lesions produced by ionizing radiation are
by far more cytotoxic than isolated AP lesion entities. The structure and dynamics of a series …

Histone tails in nucleosomes play critical roles in regulation of many biological processes,
including chromatin compaction, transcription, and DNA repair. Moreover, post-translational …

Epigenetic modifications of histone N-terminal tails play a critical role in regulating the
chromatin structure and biological processes such as transcription and DNA repair. One of …

Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesions that are highly mutagenic and
cytotoxic if not repaired. In addition, clusters of two or more abasic lesions within one to two …

Histone tails and their epigenetic modifications play crucial roles in gene expression
regulation by altering the architecture of chromatin. However, the structural mechanisms by …

In nucleosomes, the access of DNA lesions to nucleotide excision repair is hindered by
histone proteins. However, evidence that the nature of the DNA lesions may play a role in …

Nucleosomes, basic units of chromatin, are known to show spontaneous DNA unwrapping
dynamics that are crucial for transcriptional activation, but its structural details are yet to be …