During the periovulatory period, the cervix of the ewe relaxes and this mechanism is thought
to be mediated by oxytocin and prostaglandin E 2 (PGE 2) in response to increased …

The ovine cervix relaxes at estrus allowing easier entry of spermatozoa into the uterus. The
mechanism responsible for this relaxation is not fully elucidated and we hypothesized that …

There is a degree of cervical relaxation in the ewe at estrus that is regulated by changes in
prostaglandin synthesis, prostaglandin receptor expression, and changes in the cervical …

Prostaglandin E2 (PGE2) can cause softening of the bovine cervix at oestrus when receptors
for oxytocin (OT) are maximally present, indicating a relationship between OT and PGE2 …

Artificial insemination in sheep has two major limiting factors: the poor quality of frozen-
thawed ram semen and the convoluted anatomy of the sheep cervix that does not allow …

The purposes of this study were to determine the separate and interactive functions of
progesterone and estradiol in regulating the cervical prostaglandin (PG) system in pregnant …

The effects and mechanism of action of prostaglandin E2 (PGE2) on the ovine cervix are
largely unknown in the luteal phase. In these studies we have shown that low levels of EP3 …

The effects of an inhibitor of 3β-hydroxysteroid dehydrogenase (epostane) on uterine activity
and cervical softening have been studied in eight sheep during late pregnancy. Treatment …

The aim was to investigate the histologic distribution of estrogen receptor α (ERα), oxytocin
receptor (OxR), LH receptor (LHR), and cyclooxygenase-2 (COX-2) in the cervix of the ewe …

Although prostaglandin E 2 (PGE 2) has been identified as a central mediator of the cervical
ripening process, the mechanisms responsible for PGE 2 ripening are still poorly …