Introduction: Receptor tyrosine kinases (RTKs) are validated targets for oncology drug
discovery and RTK antagonists are available to treat human malignancies. Nonetheless, the …

Introduction 3. Structure and biological functions of ErbB receptors 4. Regulation of receptor
activity 4.1. ErbB Ligands 4.2. Receptor activation and signaling 4.3. Receptor …

Drugs for specific molecular targets have generated a great deal of excitement for their
potential in cancer treatment, particularly with respect to our molecular understanding of …

The erbB family of receptor tyrosine kinases is composed of growth factor receptors that are
overexpressed or mutated in a large variety of human cancers. The study of erbB-mediated …

The erbB family of tyrosine kinases represents a versatile set of four plasma membrane
receptors that possesses enormous diversity in signaling capability. The rationale to target …

ErbB1 and ErbB2 constitute validated target antigens for tumor therapy—as documented by
the approval of antibodies and tyrosine kinase inhibitors (TKIs) against both antigens …

ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …

The ErbB receptors are localized to the cell membrane where they are activated by ligand to
trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB …

The overexpression and aberrant function of members of the erbB family of receptors,
particularly erbB1 (also known as epidermal growth factor receptor), and its ligands in many …

Tyrosine kinases are a large and diverse family of proteins found only in metazoans. The
ERBB family, which encompasses subgroup I of the receptor tyrosine kinase (RTK) …