The TIME acronym (tissue, infection/inflammation, moisture balance and edge of wound)
was first developed more than 10 years ago, by an international group of wound healing …

Management of chronic wounds has progressed from merely assessing the status of a
wound to understanding the underlying molecular and cellular abnormalities that prevent …

Wound healing is a complex and highly regulated process that can be compromised by both
endogenous factors (pathophysiological) and exogenous factors (micro-organisms) …

Managing chronic wounds has progressed from merely assessing the wound to
understanding the underlying cellular abnormalities and associated clinical problems. The …

Wound bed preparation is now a well established concept and the TIME framework has
been developed as a practical tool to assist practitioners when assessing and managing …

Despite the understanding that wounds are a common problem affecting the individual, the
health service and society as a whole, there continues to be a lack of a systematic …

Infection is the likeliest single cause of delayed healing in healing of chronic open wounds
by secondary intention. If neglected it can progress from contamination to colonization and …

Significance: Successful treatment of wounds relies on precise control and continuous
monitoring of the wound-healing process. Wet or moist treatment of wounds has been …

While the overwhelming majority of wounds heal rapidly, a significant proportion fail to
progress through the wound‐healing process. These resultant chronic wounds cause …

The immense burden imposed by chronic wounds—those persisting over 6 weeks despite
active intervention—on patients and health services is well recognised. There are various …