R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are
physiological structures that regulate various cellular processes occurring on chromatin …

R-loops are non-B DNA structures that form during transcription when the nascent RNA
anneals to the template DNA strand forming a RNA: DNA hybrid. Understanding the …

DNA transcription and replication are two essential physiological processes that can turn
into a threat for genome integrity when they compete for the same DNA substrate. During …

Elongation of RNA polymerase II (Pol II) is affected by many factors including DNA damage.
Bulky damage, such as lesions caused by ultraviolet (UV) radiation, arrests Pol II and …

R-loops form when transcribed RNA remains bound to its DNA template to form a stable
RNA: DNA hybrid. Stable R-loops form when the RNA is purine-rich, and are further …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

Genome instability via RNA: DNA hybrid-mediated R loops has been observed in mutants
involved in various aspects of transcription and RNA processing. The prevalence of this …

Arrest of transcription at sites of DNA damage represents a strong signal for apoptosis. To
overcome the impasse represented by transcription complexes arrested at sites of damage …

Nonscheduled R loops represent a major source of DNA damage and replication stress.
Cells have different ways to prevent R-loop accumulation. One mechanism relies on the …

R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play
important biological roles and are implicated in pathology. Even so, proteins recognizing …