Many cellular systems exist in more than one state. Two of the simplest and best-
characterized examples are bacteriophage A, which can be in the lytic or lysogenic state …

A cell lineage is the ancestral relationship between a group of cells that originate from a
single founder cell. For example, in the embryo of the nematode Caenorhabditis elegans an …

The regulatory systems that allow cells to adapt to their environments are exceedingly
complex, and although we know a great deal about the intricate mechanistic details of many …

Mathematical models of stem cell differentiation are commonly based upon the concept of
subsequent cell fate decisions, each controlled by a gene regulatory network. These …

Molecular mechanisms employed by individual multipotent cells at the point of lineage
commitment remain largely uncharacterized. Current paradigms span from instructive to …

Phenotypical diversity may arise despite clonal genetics for a number of reasons, many of
which are due to fluctuations in the environment: for example, cells nearer to nutrient …

Modern biology will never be the same without mathematical and computational tools. Using
mind map with “epigenetics” as the root, we discuss the current advancement in the field of …

Models describing the process of stem-cell differentiation are plentiful, and may offer insights
into the underlying mechanisms and experimentally observed behaviour. Waddington's …

Traditionally molecular biology research has tended to reduce biological pathways to
composite units studied as isolated parts of the cellular system. With the advent of high …

Cell fate decisions are controlled by complex intracellular molecular regulatory networks.
Studies increasingly reveal the scale of this complexity: not only do cell fate regulatory …