[HTML][HTML] Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

HC Verdera, JJ Gitz-Francois, RM Schiffelers… - Journal of Controlled …, 2017 - Elsevier
Recent evidence has established that extracellular vesicles (EVs), including exosomes and
microvesicles, form an endogenous transport system through which biomolecules, including …

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

K O'Brien, S Ughetto, S Mahjoum, AV Nair… - Cell reports, 2022 - cell.com
Extracellular vesicles (EVs) are membrane-encapsulated particles that carry genetically
active and protein/lipid cargo that can affect the function of the recipient cell. A number of …

Extracellular vesicles: composition, biological relevance, and methods of study

MŁP Zaborowski, L Balaj, XO Breakefield, CP Lai - Bioscience, 2015 - academic.oup.com
The release of extracellular vesicles (EVs), including exosomes and microvesicles, is a
phenomenon shared by many cell types as a means of communicating with other cells and …

Strategic design of extracellular vesicle drug delivery systems

JPK Armstrong, MM Stevens - Advanced drug delivery reviews, 2018 - Elsevier
Abstract Extracellular vesicles (EVs), sub-micron vectors used in intercellular
communication, have demonstrated great promise as natural drug delivery systems. Recent …

[HTML][HTML] Extracellular vesicles: exosomes, microvesicles, and friends

G Raposo, W Stoorvogel - The Journal of cell biology, 2013 - ncbi.nlm.nih.gov
Cells release into the extracellular environment diverse types of membrane vesicles of
endosomal and plasma membrane origin called exosomes and microvesicles, respectively …

Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Extracellular vesicles: unique intercellular delivery vehicles

SLN Maas, XO Breakefield, AM Weaver - Trends in cell biology, 2017 - cell.com
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Achieving the promise of therapeutic extracellular vesicles: the devil is in details of therapeutic loading

DS Sutaria, M Badawi, MA Phelps… - Pharmaceutical …, 2017 - Springer
Extracellular vesicles (EVs) represent a class of cell secreted organelles which naturally
contain biomolecular cargo such as miRNA, mRNA and proteins. EVs mediate intercellular …

Differential fates of biomolecules delivered to target cells via extracellular vesicles

M Kanada, MH Bachmann, JW Hardy… - Proceedings of the …, 2015 - National Acad Sciences
Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …