Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is
essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative …

The normal function of the mitochondria is crucial for most tissues especially for those that
demand a high energy supply. Emerging evidence has pointed out that healthy …

Mitophagy is an autophagic process through which damaged or dysfunctional mitochondria
are specifically degraded to maintain cellular homeostasis. It is highly regulated by various …

Mitophagy is one of the important targets for the prevention and treatment of myocardial
ischemia/reperfusion injury (MIRI). Moderate mitophagy can remove damaged mitochondria …

Aims Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of
autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function …

Ischemia-reperfusion injury (IR injury), produced by initial interruption and subsequent
restoration of organ blood flow, is an important clinical dilemma accompanied by various …

Mitochondria are dynamic organelles that can undergo fusion, fission, biogenesis, and
autophagic elimination to maintain mitochondrial quality control. Since the heart is in …

Myocardial ischemia reduces the supply of oxygen and nutrients to cardiomyocytes, leading
to an energetic crisis or cell death. Mitochondrial dysfunction is a decisive contributor to the …

Healthy mitochondrial function is imperative for most tissues, but especially those with a high
energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular …

Cardiovascular disease (CVD) leads to high morbidity and mortality rates worldwide.
Accumulating evidence has revealed that mitochondria dysfunction is implicated in CVD …