Emerging evidence suggests that partially distinct mechanisms may underlie the association
between different dimensions of early life adversity (ELA) and psychopathology in children …

Early-life adversity (ELA) is strongly associated with risk for psychopathology. Within
adversity, deprivation, and threat may lead to psychopathology through different …

Exposure to early life adversity (ELA) is associated with increased rates of psychopathology
and poor physical health. The present study builds on foundational work by Megan Gunnar …

Importance Adverse childhood experiences (ACEs) have been associated with poor mental
and physical health outcomes. However, the mechanism of this effect, critical to enhancing …

Despite long-standing interest in the influence of adverse early experiences on mental
health, systematic scientific inquiry into childhood adversity and developmental outcomes …

Objective Dysregulation of autonomic nervous system and hypothalamic-pituitary-adrenal
(HPA) axis function is a putative intermediate phenotype linking childhood adversity (CA) …

Background Recent conceptual models argue that early life adversity (ELA) accelerates
development, which may contribute to poor mental and physical health outcomes. Evidence …

Adverse childhood experiences (ACEs) are complex early stressors that may disrupt normal
developmental processes in each area of the biopsychosocial model. Specifically, ACEs …

Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …

Current frameworks for understanding the link between early adverse childhood
experiences and later negative life outcomes, including psychopathology, focus on the …