PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE …

F Depetri - 2022 - air.unimi.it
Angioedema is a swelling of the subcutaneous and submucosal tissues that can involve lips,
face, neck, extremities and/or submucosal tissues of the oral cavity, larynx and intestine …

Bradykinin and the pathophysiology of angioedema

M Cugno, J Nussberger, M Cicardi… - International …, 2003 - Elsevier
Angioedema has different causes and different clinical presentations. Some types of
angioedema may be mediated by bradykinin. We measured plasma levels of bradykinin-(1 …

Non‐histaminergic angioedema: focus on bradykinin‐mediated angioedema

PJ Busse, MS Buckland - Clinical & Experimental Allergy, 2013 - Wiley Online Library
Angioedema is a result of increased vascular permeability, with subsequent extravasation of
intravascular fluid into the surrounding tissues. Angioedema may be mediated by histamine …

Measurement of bradykinin formation and degradation in blood plasma: relevance for acquired angioedema associated with angiotensin converting enzyme inhibition …

F Marceau, GE Rivard, JM Gauthier, KE Binkley… - Frontiers in …, 2020 - frontiersin.org
Bradykinin (BK)-mediated angioedema (AE) states are rare acquired or hereditary
conditions involving localized edema of the subcutaneous and submucosal tissues. Citrated …

The bradykinin-forming cascade and its role in hereditary angioedema

AP Kaplan, K Joseph - Annals of Allergy, Asthma & Immunology, 2010 - Elsevier
OBJECTIVE: To review the mechanisms by which bradykinin is generated in hereditary
angioedema (HAE)(C1 inhibitor deficiency), including the role of human plasma proteins …

Current pharmacotherapy of bradykinin-mediated angioedema

H Farkas - Expert opinion on pharmacotherapy, 2013 - Taylor & Francis
Introduction: Bradykinin-mediated angioedema is characterized by subcutaneous and/or
submucosal edema formation without wheals and pruritus. It is linked to bradykinin …

Angioedema due to bradykinin dysregulation

M Cicardi, BL Zuraw - The Journal of Allergy and Clinical Immunology: In …, 2018 - Elsevier
Angioedema is an acute swelling of the deeper layers of the skin or mucosa resulting from a
transient increase in vascular permeability. Angioedema can occur in the absence or …

Bradykinin analysis revived–a validated method for determination of its stable metabolite in whole blood by LC–MS/MS

KF Seip, KC Bjerknes, HT Johansen… - … of Chromatography B, 2014 - Elsevier
Investigation of bradykinin involvement in diseases like hereditary angioedema has been
greatly hindered by its rapid metabolism and generation, induced by sampling. Because of …

Enzymatic assays for the diagnosis of bradykinin-dependent angioedema

F Defendi, D Charignon, A Ghannam, R Baroso… - PLoS …, 2013 - journals.plos.org
Background The kinins (primarily bradykinin, BK) represent the mediators responsible for
local increase of vascular permeability in hereditary angioedema (HAE), HAE I-II associated …

[HTML][HTML] Drug-induced inhibition of angiotensin converting enzyme and dipeptidyl peptidase 4 results in nearly therapy resistant bradykinin induced angioedema: a …

J Hahn, S Trainotti, TK Hoffmann… - The American journal of …, 2017 - ncbi.nlm.nih.gov
Objective: Unusual clinical course Background: Bradykinin is an underestimated mediator of
angioedema. One subgroup of bradykinin induced angioedema is angioedema triggered by …