Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety

B Chen, L Wang, L Li, R Zhu, H Liu, C Liu, R Ma, Q Jia… - Molecules, 2017 - mdpi.com
Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an
alternative medicine in the prevention and treatment of osteoporosis. This study aimed to …

Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats

B Chen, J Wei, R Zhu, H Zhang, B Xia, Y Liu… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Fructus Ligustri Lucidi (FLL) is an edible herb with
anti-osteoporotic activity, yet whether and how the aqueous extract of this herb affect calcium …

Fructus Ligustri Lucidi modulates estrogen receptor expression with no uterotrophic effect in ovariectomized rats

Y Tang, C Li, X Sun, Y Liu, X Wang, Y Guo… - … and alternative medicine, 2018 - Springer
Background Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a
beneficial role in preventing the development of osteoporosis. However, the effects of FLL …

Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats

CH Ko, WS Siu, CP Lau, CBS Lau, KP Fung… - Chinese Medicine, 2010 - Springer
Abstract Background Fructus Ligustri Lucidi (FLL) is a commonly used herb for treating bone
disorders in Chinese medicine. The present study investigates the anti-osteoporotic activity …

Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice

X Qin, Q Wei, R An, Y Yang, M Cai, X Han… - Pharmaceutical …, 2023 - Taylor & Francis
Abstract Context Fructus Ligustri Lucidi (FLL), a commonly used herb of traditional Chinese
medicine (TCM), is the fruit of Ligustrum lucidum Ait.(Oleaceae). The ethanol extract of FLL …

Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β‐catenin signaling pathway in ovariectomized rats

H Liu, Y Guo, R Zhu, L Wang, B Chen… - Phytotherapy …, 2021 - Wiley Online Library
Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat
musculoskeletal diseases. However, whether and how FLL affect the canonical Wnt/β …

Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells

G Li, X Zhang, J Zhang, C Chan… - … Journal Devoted to …, 2010 - Wiley Online Library
Abstract Fructus Ligustri Lucidi (FLL) has been used in traditional Chinese medicine for over
1000 years. The ethanol extract of FLL (EFLL) has been shown to be a potential candidate …

Fructus Ligustri Lucidi (FLL) ethanol extract increases bone mineral density and improves bone properties in growing female rats

Y Lyu, X Feng, P Zhao, Z Wu, H Xu, Y Fang… - Journal of bone and …, 2014 - Springer
Osteoporosis is a chronic disease affecting millions of people worldwide. It is generally
accepted that acquisition of a high peak bone mass (PBM) early in life can reduce the risk of …

Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats

Y Zhang, WP Lai, PC Leung, CT Che… - Osteoporosis …, 2008 - Springer
This study aimed to demonstrate and delineate the mechanism of action of Fructus Ligustri
Lucidi (FLL) involved in improving Ca balance in aged female rats. FLL could enhance the …

Fructus ligustri lucidi Ethanol Extract Improves Bone Mineral Density and Properties Through Modulating Calcium Absorption-Related Gene Expression in Kidney …

X Feng, Y Lyu, Z Wu, Y Fang, H Xu, P Zhao… - Calcified Tissue …, 2014 - Springer
Optimizing peak bone mass in early life is one of key preventive strategies against
osteoporosis. Fructus ligustri lucidi (FLL), the fruit of Ligustrum lucidum Ait., is a commonly …