Highlights•Brain P450 enzymes constitute an extra-hepatic line of drug metabolism.•P450s
expressed in brain cells contribute to neurotoxicity or neuroprotection.•Neurovascular P450 …

The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many exogenous
and endogenous compounds. CYPs are abundant in the liver and are also expressed in …

Cytochrome P450 (CYP, P450) is the collective term for a superfamily of heme-containing
membrane proteins responsible for the metabolism of∼ 70-80% of clinically used drugs …

Advances in a multitude of disciplines support an emerging role for cytochrome P450
enzymes and their metabolic substrates and end-products in the pathogenesis and …

Introduction: Cytochromes P450 (P450) and associated monooxygenases are a family of
heme proteins involved in metabolism of endogenous compounds (arachidonic acid …

The functional role of cytochrome P450 (CYP) enzymes in the brain is an exciting and
evolving field of research. CYPs are present and active in the brain, with heterogeneous …

Cytochromes P450 (CYPs) constitute a family of enzymes that can be found in the
endoplasmic reticulum (ER), mitochondria or the cell surface of the cells. CYPs are …

Individuals vary in their response to centrally acting drugs, and this is not always predicted
by drug plasma levels. Central metabolism by brain cytochromes P450 (CYPs) may …

Drug penetration into the central nervous system (CNS) is controlled by the blood-brain
barrier (BBB). Even though a number of strategies to circumvent the BBB and to improve …