Metformin limits osteoarthritis development and progression through activation of AMPK signalling
Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA)
development and progression. Methods Destabilisation of the medial meniscus (DMM) …
development and progression. Methods Destabilisation of the medial meniscus (DMM) …
[HTML][HTML] Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior
Background Metformin could activate adenosine monophosphate-activated protein kinase
(AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study …
(AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study …
[HTML][HTML] Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
X Feng, J Pan, J Li, C Zeng, W Qi, Y Shao, X Liu… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
Background: It is generally thought that the occurrence and progression of osteoarthritis
(OA) results from multiple causes, including degradation and destruction of the cartilage …
(OA) results from multiple causes, including degradation and destruction of the cartilage …
[HTML][HTML] Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway
H Guo, D Ding, L Wang, J Yan, L Ma, Q Jin - PLoS One, 2021 - journals.plos.org
This study explored the mechanism by which metformin (Met) inhibits osteoclast activation
and determined its effects on osteoarthritis (OA) mice. Bone marrow-derived macrophages …
and determined its effects on osteoarthritis (OA) mice. Bone marrow-derived macrophages …
Peroxisome proliferator–activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP‐activated protein kinase
X Zhao, F Petursson, B Viollet, M Lotz… - Arthritis & …, 2014 - Wiley Online Library
Objective AMP‐activated protein kinase (AMPK) inhibits chondrocyte procatabolic
responses to inflammation and biomechanical injury. This study was undertaken to test the …
responses to inflammation and biomechanical injury. This study was undertaken to test the …
[HTML][HTML] Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes
Introduction AMP-activated protein kinase (AMPK) maintains cultured chondrocyte matrix
homeostasis in response to inflammatory cytokines. AMPK activity is decreased in human …
homeostasis in response to inflammatory cytokines. AMPK activity is decreased in human …
Chondrocyte AMP‐activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin‐1β and tumor necrosis factor α
R Terkeltaub, B Yang, M Lotz… - Arthritis & …, 2011 - Wiley Online Library
Abstract Objective Interleukin‐1β (IL‐1β) and tumor necrosis factor α (TNFα) stimulate
chondrocyte matrix catabolic responses, thereby compromising cartilage homeostasis in …
chondrocyte matrix catabolic responses, thereby compromising cartilage homeostasis in …
[HTML][HTML] Metformin: a potential therapeutic tool for rheumatologists
Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes, acting via
indirect activation of 5′ Adenosine Monophosphate-activated Protein Kinase (AMPK) …
indirect activation of 5′ Adenosine Monophosphate-activated Protein Kinase (AMPK) …
[HTML][HTML] Metformin attenuates monosodium-iodoacetate-induced osteoarthritis via regulation of pain mediators and the autophagy–lysosomal pathway
HS Na, JY Kwon, SY Lee, SH Lee, AR Lee, JS Woo… - Cells, 2021 - mdpi.com
Osteoarthritis (OA) is the most common degenerative arthritis associated with pain and
cartilage destruction in the elderly; it is known to be involved in inflammation as well. A drug …
cartilage destruction in the elderly; it is known to be involved in inflammation as well. A drug …
[HTML][HTML] AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice
S Zhou, W Lu, L Chen, Q Ge, D Chen, Z Xu, D Shi… - Scientific Reports, 2017 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease of the joints that is associated with
both joint injury and ageing. Here, we investigated the role of the energy sensor AMP …
both joint injury and ageing. Here, we investigated the role of the energy sensor AMP …