Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host
immune response to infection. Immune response induced by sepsis is complex and …

Sepsis is the host immune imbalance following infection and leads to organ dysfunction,
with highly complicated pathophysiology. To date, sepsis still lacks effective therapies with …

Sepsis is an imbalanced response to infection that leads to life-threatening organ
dysfunction. Although an increasing number of anti-inflammatory drugs are available, the …

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation
of the inflammatory response causes oxidative stress, alterations in mitochondrial energy …

Over the past 10 years, the crisis of sepsis has remained a great challenge. According to
data from 2016, the sepsis-related mortality rate remains high. In addition, sepsis consumes …

Sepsis triggers a complex response marked by the simultaneous presence of
proinflammatory and immunosuppressive elements, disrupting the mechanisms intended to …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

The inflammasome is a molecular platform formed by activation of an innate immune pattern
recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Background The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3)
inflammasomes are intracellular protein complexes that orchestrate immune responses …