Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells

JD Kretlow, YQ Jin, W Liu, WJ Zhang, TH Hong, G Zhou… - BMC cell biology, 2008 - Springer
Background Bone marrow-derived mesenchymal stem cells (BMSCs) are a widely
researched adult stem cell population capable of differentiation into various lineages …

Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells

M Zaim, S Karaman, G Cetin, S Isik - Annals of hematology, 2012 - Springer
Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) represent a promising
cell-based therapy for a number of degenerative conditions. Many applications require cell …

Age-related changes in the frequency of mesenchymal stem cells in the bone marrow of rats

SV Tokalov, S Grüner, S Schindler, G Wolf… - Stem cells and …, 2007 - liebertpub.com
Mesenchymal stem cells (MSCs) are pluripotent cells that can differentiate into endothelial,
osteogenic, adipogenic, and other lineages. In spite of the broad interest, little is known …

Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow

P Tropel, D Noël, N Platet, P Legrand… - Experimental cell …, 2004 - Elsevier
The future use of adult mesenchymal stem cells (MSCs) for human therapies depends on
the establishment of preclinical studies with other mammals such as mouse. Surprisingly …

The stem cell potential and multipotency of human adipose tissue-derived stem cells vary by cell donor and are different from those of other types of stem cells

HJ Yang, KJ Kim, MK Kim, SJ Lee, YH Ryu… - Cells Tissues …, 2015 - karger.com
Human adipose tissue-derived mesenchymal stem cells (AT-MSCs) from various sites are
applied in tissue engineering and cell therapy. The condition of AT-MSCs depends on the …

Human mesenchymal stem cell proliferation and osteogenic differentiation during long-term ex vivo cultivation is not age dependent

S Fickert, U Schröter-Bobsin, AF Groß… - Journal of bone and …, 2011 - Springer
Mesenchymal stem cells (MSCs) are of major clinical interest for the development of cell-
based strategies to treat musculoskeletal diseases including critical-size bone defects …

Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age

V Dexheimer, S Mueller, F Braatz, W Richter - PloS one, 2011 - journals.plos.org
Mesenchymal stem cells (MSC) are promising for cell-based regeneration therapies but up
to date it is still controversial whether their function is maintained throughout ageing. Aim of …

Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells

OS Beane, VC Fonseca, LL Cooper, G Koren… - PloS one, 2014 - journals.plos.org
Mesenchymal stem/stromal cells (MSCs) are promising cell sources for regenerative
therapies due to their multipotency and ready availability, but their application can be …

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro

YHK Yang, CR Ogando, C Wang See… - Stem cell research & …, 2018 - Springer
Background Adult mesenchymal stem cells (MSCs) hold great promise for regenerative
medicine because of their self-renewal, multipotency, and trophic and immunosuppressive …

Differentiation potential of adult human mesenchymal stem cells

E Tobiasch - Stem Cell Engineering: Principles and Applications, 2011 - Springer
Mesenchymal stem cells (MSCs) can be found in various tissues of the adult organism.
These cells display a multilineage potential and can be in vitro differentiated toward the …