SHP2 is a member of the non-receptor protein tyrosine phosphatases, encoded by PTPN11,
and exhibits oncogenic activities. The close association between SHP2 and human cancer …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy, while the multifaceted roles of SHP2 complicate the drug discovery …

SHP2, a non-receptor tyrosine phosphatase, plays a pivotal role in numerous oncogenic cell-
signaling cascades like RAS-ERK, PI3K-AKT and JAK-STAT. On the other hand, proteolysis …

Phosphorylation is a reversible post-translational modification regulated by phosphorylase
and dephosphorylase to mediate important cellular events. Src homology-2-containing …

Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the
PTPN11, is a non-receptor protein tyrosine phosphatase that expressed in cytoplasmic …

Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target
for human cancers and other human diseases. Herein, we report our discovery of potent …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy. The dynamic change of SHP2 between closed and open …

Abstract Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded
by PTPN11, regulates cell proliferation, differentiation, apoptosis and survival via releasing …

Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive target for cancer
therapy due to its multifaceted roles in both tumor and immune cells. Herein, we designed …

Protein tyrosine phosphatase SHP2 is a member of PTPs family associated with cancer such
as leukemia, non-small cell lung cancer, breast cancer, and so on. SHP2 is a promising …