The orthotopic model reproduces aspects of the tumour microenvironment and emulates a
number of important biological features of cancer progression, angiogenesis, metastasis …

Currently-used rodent tumor models, including transgenic tumor models, or subcutaneously
growing human tumors in immunodeficient mice, do not sufficiently represent clinical-cancer …

Purpose: This study was conducted to develop biologically relevant animal models of
human lung cancer that are reproducible, inexpensive, and easy to perform. Experimental …

Animal models have been critical in the study of the molecular mechanisms of cancer and in
the development of new antitumor agents; nevertheless, there is still much room for …

Numerous vaso-active agents can affect vasculature in experimental solid tumours growing
subcutaneously (sc), but these models are unlikely to reflect the vasculature of metastatic …

Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of
cancer and elucidation of their mechanisms of action require the use of relevant animal …

The host microenvironment plays a prominent role in tumor growth, angiogenesis, invasion,
metastasis, and response to therapy. Orthotopic tumor model mimics the natural …

Considering the enormous effort that has taken place over the years to discover new
chemotherapeutic drugs for treating the common cancers, the conventional murine and …

Mouse models of disease play a pivotal role at all stages of cancer drug development. Cell-
line derived subcutaneous tumour models are predominant in early drug discovery, but …

With greater technological advancements and understanding of pathophysiology,“
personalized medicine” has become a more realistic goal. In the field of cancer …