Spinal commissural axon navigation across the midline in the floor plate requires repulsive
forces from local Slit repellents. The long-held view is that Slits push growth cones forward …

Summary Sensitization to Slits and Semaphorin (Sema) 3B floor plate repellents after
midline crossing is thought to be the mechanism expelling commissural axons …

Growth cone guidance is driven by attractive and repulsive signaling cues. Until recently,
repulsive signaling by semaphorins was thought to be mediated through Plexin receptors …

Accurate perception of guidance cues is crucial for cell and axon migration. During initial
navigation in the spinal cord, commissural axons are kept insensitive to midline repellents …

Commissural axon guidance depends on a myriad of cues expressed by intermediate
targets. Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on …

Abstract Robo-Slit and Plexin-Semaphorin signaling participate in various developmental
and pathogenic processes. During commissural axon guidance in the spinal cord …

During nervous system development, gradients of Sonic Hedgehog (Shh) and Netrin-1
attract growth cones of commissural axons toward the floor plate of the embryonic spinal …

In vertebrates, spinal commissural axons project along a transverse path toward and across
the floor plate (FP). Post-crossing commissural axons alter their responsiveness to FP …

In the developing nervous system, pathfinding axons navigate through a series of
intermediate targets in order to form synaptic connections. Vertebrate spinal commissural …

Commissural axon guidance requires complex modulations of growth cone sensitivity to
midline-derived cues, but underlying mechanisms in vertebrates remain largely unknown …