Staphylococcus aureus and Acinetobacter baumannii inhibit osseointegration of orthopedic implants

H Choe, JM Tatro, BS Hausman, KM Hujer… - Infection and …, 2022 - Am Soc Microbiol
Bacterial infections routinely cause inflammation and thereby impair osseointegration of
orthopedic implants. Acinetobacter spp., which cause osteomyelitis following trauma, on or …

Emerging Pathogenetic Mechanisms of the Implant-Related Osteomyelitis by Staphylococcus Aureus

L Montanaro, F Testoni, A Poggi… - … journal of artificial …, 2011 - journals.sagepub.com
Implant-related osteomyelitis is a severe and deep infection of bone that arises and
develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis …

Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice

EA Masters, SP Hao, HM Kenney… - Journal of …, 2021 - Wiley Online Library
Osteomyelitis is a devastating complication of orthopaedic surgery and commonly caused by
Staphylococcus aureus (S. aureus) and Group B Streptococcus (GBS, S. agalactiae) …

Quantitative mouse model of implant‐associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity

D Li, K Gromov, K Søballe, JE Puzas… - Journal of …, 2008 - Wiley Online Library
Although osteomyelitis (OM) remains a serious problem in orthopedics, progress has been
limited by the absence of an in vivo model that can quantify the bacterial load, metabolic …

[PDF][PDF] Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration

H Choe, BS Hausman, KM Hujer, O Akkus… - European Cells & …, 2022 - ecmjournal.org
Implant infection impairs osseointegration of orthopaedic implants by inducing inflammation.
Acinetobacter spp. are increasingly prevalent multi-drug resistant bacteria that can cause …

Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis

CR Arciola, GM Hänsch, L Visai… - … journal of artificial …, 2012 - journals.sagepub.com
In spite of great advancements in the field of biomaterials and in surgical techniques, the
implant of medical devices is still associated with a high risk of bacterial infection. Implant …

Orthopedic implant infections: Incompetence of Staphylococcus epidermidis, Staphylococcus lugdunensis, and Enterococcus faecalis to invade osteoblasts

D Campoccia, F Testoni, S Ravaioli… - … Research Part A, 2016 - Wiley Online Library
Septic failure is still the major complication of prosthetic implants. Entering host cells,
bacteria hide from host immune defenses, shelter from extracellular antibiotics, and cause …

A simple infection model using pre‐colonized implants to reproduce rat chronic Staphylococcus aureus osteomyelitis and study antibiotic treatment

M Monzon, F García‐Álvare, A Lacleriga… - Journal of …, 2001 - Wiley Online Library
Staphylococcus aureus biofilms formed on medical implants represent a serious problem,
being difficult to eradicate with antibiotic therapy and leading to chronic infections. Simplified …

Bacterial colonization of bone allografts: establishment and effects of antibiotics

C Ketonis, S Barr, CS Adams, NJ Hickok… - … and Related Research …, 2010 - journals.lww.com
Background Bone grafts are frequently used to supplement bone stock and to establish
structural stability. However, graft-associated infection represents a challenging …

Monitoring immune responses in a mouse model of fracture fixation with and without Staphylococcus aureus osteomyelitis

ETJ Rochford, MS Brescó, S Zeiter, K Kluge… - Bone, 2016 - Elsevier
Post-traumatic bone fractures are commonly fixed with implanted devices to restore the
anatomical position of bone fragments and aid in the healing process. Bacterial infection in …