We recently reported a cationic lipid-based vector of siRNA, termed siRNA lipoplex that was
very efficient in specific gene silencing, both in cell culture and in mouse disease models. To …

We previously designed a new siRNA vector that efficiently silences genes in vitro and in
vivo. The vector originality is based on the fact that, in addition to the siRNA molecule, it …

RNA interference (RNAi) has become a popular tool for downregulating specific gene
expression in many species, including mammalian cells [Novina, CD, and Sharp, PA (2004) …

Cationic liposomes (LPs) have been utilized for short interfering RNA (siRNA) delivery in
vitro and in vivo owing to their high affinity for siRNA via electrostatic binding. However, both …

RNA interference, the sequence-specific silencing of gene expression by introduction of
short interfering RNA (siRNA) is a powerful tool that that the potential to act as a therapeutic …

Small interference RNA (siRNA) is an important research tool, and also has the potential for
clinical application. RNA interference (RNAi) approaches allow degradation of selective …

Novel formulations based on physiologically occurring anionic lipids have been designed to
achieve safe and efficient siRNA delivery. Anionic liposomes (DOPG/DOPE) were …

Background RNA interference provides a powerful technology for specific gene silencing.
Therapeutic applications of small interfering RNA (siRNA) however require efficient vehicles …

In this study, we developed anionic polymer-coated liposome/siRNA complexes (lipoplexes)
with chondroitin sulfate C (CS), poly-l-glutamic acid (PGA) and poly-aspartic acid (PAA) for …

In this study, we examined the effect of neutral helper lipids in cationic liposomes on gene
silencing efficacy in the lungs after intravenous injection of cationic liposomes/siRNA …