Background A decrease in nitric oxide (NO) bioavailability has been shown to cause
hyperglycemia, type II diabetes mellitus (DM), and chronic cardio-metabolic complications …

Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously
reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME) …

Abstract L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric
oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in …

This study tested the hypothesis that dietary arginine supplementation increases endothelial
tetrahydrobiopterin (BH 4) availability for nitric oxide (NO) synthesis in diabetic rats …

Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease.
One of the early signs of T2DM associated cardiovascular events is the development of …

Rat studies demonstrated that type II diabetes mellitus (T2DM) decreases both the
production and bioavailability of nitric oxide (NO). L‐arginine (LA) provides the precursor for …

This study investigated the temporal activation of arginase in obese Zucker rats (ZR) and
determined if arginase inhibition prevents the development of hypertension and improves …

Diabetes mellitus leads to the development of endothelial dysfunction which finally
contributes to diabetic angiopathy. We investigated the effects of hyperglycaemia on nitric …

We tested the hypothesis that activation of the polyol pathway and protein kinase C (PKC)
during diabetes is due to loss of NO. Our results show that after 4 weeks of streptozotocin …

Diabetic subjects exhibit low levels of nitric oxide (NO), its precursor l-arginine, and nitric
oxide synthase (NOS) in tissues like endothelium and kidney. In view of this, we speculated …