Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular
matrix (ECM), and its over expression in human prostate cancer has been associated with …

Osteopontin is a secreted glycosylated phosphoprotein known to be involved in numerous
physiologic functions and associated with the late stages of various cancers. We used …

Osteopontin (OPN) is a protein, generally considered to play a pro‐tumorigenic role,
whereas several reports have demonstrated the anti‐tumorigenic function of OPN during …

Androgen receptor (AR) signaling is a key pathway modulating prostate cancer (PCa)
progression. Several steps in this pathway have been investigated in order to propose novel …

Osteopontin (OPN) is a phosphoprotein that activates several aspects of tumor progression.
Alternative splicing of the OPN primary transcript generates three splicing isoforms, OPNa …

Osteopontin (OPN) has been recognized as a significant cytokine in the processes of
tumorigenicity, tumor progression and metastasis in many types of human cancer. However …

Abstract Objectives: Osteopontin (OPN), a secreted adhesive glycoprotein, has been shown
to be produced in excessive amounts in a variety of experimental models of malignancy …

Background Especially in human tumor cells, the osteopontin (OPN) primary transcript is
subject to alternative splicing, generating three isoforms termed OPNa, OPNb and OPNc …

Simple Summary Bone metastasis can develop from several tumor subtypes, and the
presence of bone metastasis confers a negative prognosis to patients. In dogs, a small …

Human prostate cancer has the propensity to metastasize to the bone where reciprocal
cellular interactions between prostate cancer and bone cells are known to occur …