Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance
SA McMahon, GA Roberts, KA Johnson… - Nucleic acids …, 2009 - academic.oup.com
The ardA gene, found in many prokaryotes including important pathogenic species, allows
associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems …
associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems …
Plasmid R16 ArdA Protein Preferentially Targets Restriction Activity of the Type I Restriction-Modification System EcoKI
AT Thomas, WJ Brammar, BM Wilkins - Journal of bacteriology, 2003 - Am Soc Microbiol
The ArdA antirestriction protein of the IncB plasmid R16 selectively inhibited the restriction
activity of Eco KI, leaving significant levels of modification activity under conditions in which …
activity of Eco KI, leaving significant levels of modification activity under conditions in which …
The Orf18 gene product from conjugative transposon Tn916 is an ArdA antirestriction protein that inhibits type I DNA restriction–modification systems
D Serfiotis-Mitsa, GA Roberts, LP Cooper… - Journal of molecular …, 2008 - Elsevier
Gene orf18, which is situated within the intercellular transposition region of the conjugative
transposon Tn916 from the bacterial pathogen Enterococcus faecalis, encodes a putative …
transposon Tn916 from the bacterial pathogen Enterococcus faecalis, encodes a putative …
The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro
D Serfiotis-Mitsa, AP Herbert, GA Roberts… - Nucleic acids …, 2010 - academic.oup.com
Plasmids, conjugative transposons and phage frequently encode anti-restriction proteins to
enhance their chances of entering a new bacterial host that is highly likely to contain a Type …
enhance their chances of entering a new bacterial host that is highly likely to contain a Type …
Plasmid-encoded antirestriction protein ArdA can discriminate between type I methyltransferase and complete restriction–modification system
SV Nekrasov, OV Agafonova, NG Belogurova… - Journal of molecular …, 2007 - Elsevier
Many promiscuous plasmids encode the antirestriction proteins ArdA (alleviation of
restriction of DNA) that specifically affect the restriction activity of heterooligomeric type I …
restriction of DNA) that specifically affect the restriction activity of heterooligomeric type I …
A motif conserved among the type I restriction-modification enzymes and antirestriction proteins: a possible basis for mechanism of action of plasmid-encoded …
AA Belogurov, EP Delver - Nucleic acids research, 1995 - academic.oup.com
ABSTRACT Antirestriction proteins Ard encoded by some self-transmissible plasmids
specifically inhibit restriction by members ofall three families of type I restriction-modification …
specifically inhibit restriction by members ofall three families of type I restriction-modification …
Distribution of the ardA family of antirestriction genes on conjugative plasmids
PM Chilley, BM Wilkins - Microbiology, 1995 - microbiologyresearch.org
The ardA gene of I1 plasmid Collb-P9 was previously shown to alleviate DNA restriction by
type I enzymes and to promote conjugative transmission of the unmodified plasmid to a …
type I enzymes and to promote conjugative transmission of the unmodified plasmid to a …
[HTML][HTML] ArdA proteins from different mobile genetic elements can bind to the EcoKI Type I DNA methyltransferase of E. coli K12
K Chen, M Reuter, B Sanghvi, GA Roberts… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Anti-restriction and anti-modification (anti-RM) is the ability to prevent cleavage by DNA
restriction–modification (RM) systems of foreign DNA entering a new bacterial host. The …
restriction–modification (RM) systems of foreign DNA entering a new bacterial host. The …
Plasmid pKM101 encodes two nonhomologous antirestriction proteins (ArdA and ArdB) whose expression is controlled by homologous regulatory sequences
AA Belogurov, EP Delver, OV Rodzevich - Journal of bacteriology, 1993 - Am Soc Microbiol
The IncN plasmid pKM101 (a derivative of R46) encodes the antirestriction protein ArdB
(alleviation of restriction of DNA) in addition to another antirestriction protein, ArdA …
(alleviation of restriction of DNA) in addition to another antirestriction protein, ArdA …
Antirestriction protein Ard (Type C) encoded by IncW plasmid pSa has a high similarity to the “protein transport” domain of TraC1 primase of promiscuous plasmid RP4
AA Belogurov, EP Delver, OV Agafonova… - Journal of molecular …, 2000 - Elsevier
The IncW plasmid pSa contains the gene ard encoding an antirestriction function that is
specific for type I restriction and modification systems. The nucleotide sequence of ard was …
specific for type I restriction and modification systems. The nucleotide sequence of ard was …