The CYP3A4 intron 6 C> T polymorphism (CYP3A4* 22) is associated with reduced CYP3A4 protein level and function in human liver microsomes
M Okubo, N Murayama, M Shimizu… - The Journal of …, 2013 - jstage.jst.go.jp
Effects of the CYP3A4 intron 6 C> T (CYP3A4* 22) polymorphism, which has recently been
reported to have a critical role in vivo, were investigated by measuring CYP3A4 protein …
reported to have a critical role in vivo, were investigated by measuring CYP3A4 protein …
CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects
S Yamaori, H Yamazaki, S Iwano, K Kiyotani… - Drug metabolism and …, 2004 - Elsevier
The purpose of this study was to evaluate a contribution of polymorphic cytochrome P450
(CYP) 3A5 to the oxidation of diltiazem, midazolam and testosterone by liver microsomes …
(CYP) 3A5 to the oxidation of diltiazem, midazolam and testosterone by liver microsomes …
Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes
M Schirmer, A Rosenberger, K Klein, B Kulle… - …, 2007 - Taylor & Francis
Objective: To find genetic markers of the individual cytochrome P450 (CYP) 3A expression.
Methods: A large collection of liver samples phenotyped for CYP3A expression and activity …
Methods: A large collection of liver samples phenotyped for CYP3A expression and activity …
CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians
K Inoue, H Yamazaki, T Shimada - Archives of toxicology, 2000 - Springer
Genotypes of CYP2A6, namely CYP2A6* 1 (wild-type), CYP2A6* 2, and CYP2A6* 3, were
examined in liver DNA of 39 Japanese and 43 Caucasians using two-step polymerase chain …
examined in liver DNA of 39 Japanese and 43 Caucasians using two-step polymerase chain …
Two novel CYP2D6* 10 haplotypes as possible causes of a poor metabolic phenotype in Japanese
M Matsunaga, H Yamazaki, K Kiyotani, S Iwano… - Drug metabolism and …, 2009 - ASPET
During the course of sequencing for the CYP2D6 gene, we found a novel single nucleotide
polymorphism of g. 3318G> A (E383K) associated with CYP2D6* 10, termed as CYP2D6 …
polymorphism of g. 3318G> A (E383K) associated with CYP2D6* 10, termed as CYP2D6 …
Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method
GF Chen, YM Tang, B Green, DX Lin… - Pharmacogenetics …, 1999 - journals.lww.com
Abstract Human cytochrome P450 2A6 (CYP2A6) has been shown to metabolically activate
carcinogens and mutagens. Genetic polymorphisms for CYP2A6 have been reported …
carcinogens and mutagens. Genetic polymorphisms for CYP2A6 have been reported …
Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans
A Paulussen, K Lavrijsen, H Bohets… - Pharmacogenetics …, 2000 - journals.lww.com
Cytochrome P450 3A subfamily members (CYP3A) are the most abundant liver cytochrome
P450 forms, responsible for the biotransformation of over 50% of all drugs. The expression …
P450 forms, responsible for the biotransformation of over 50% of all drugs. The expression …
No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins
T Tateishi, M Watanabe, H Moriya, S Yamaguchi… - Biochemical …, 1999 - Elsevier
Ethnic differences in the pharmacokinetics of nifedipine, a substrate of CYP3A, and in
CYP3A7 expression have been reported. The aim of the present study was to measure the …
CYP3A7 expression have been reported. The aim of the present study was to measure the …
CYP3A4* 16 and CYP3A4* 18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs
K Maekawa, N Harakawa, T Yoshimura, SR Kim… - Drug metabolism and …, 2010 - ASPET
CYP3A4, the major form of cytochrome P450 (P450) expressed in the adult human liver, is
involved in the metabolism of approximately 50% of commonly prescribed drugs. Several …
involved in the metabolism of approximately 50% of commonly prescribed drugs. Several …
The genetic determinants of the CYP3A5 polymorphism
E Hustert, M Haberl, O Burk, R Wolbold… - Pharmacogenetics …, 2001 - journals.lww.com
CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …