Current long duration treatment options and the emergence of drug resistance in
tuberculosis (TB) have led to renewed interest in discovery of novel anti-tubercular agents or …

Thirty-five thousand actinomycete extracts were screened for anti-Mycobacterium
tuberculosis (M. tb) activity, followed by C18 cartridge fractionation of 37 prioritized extracts …

A highly active actinobacterial strain isolated from untapped areas of Northwestern
Himalayas and characterised as Streptomyces puniceus strain AS13 by 16S rRNA gene …

This study involves the in-vitro and in-vivo anti-TB potency and in-vivo safety of Transitmycin
(TR)(PubChem CID: 90659753)-identified to be a novel secondary metabolite derived from …

Drugresistant strains of Mycobacterium tuberculosis (Mtb) undermine tuberculosis (TB)
control. Streptolydigin is a broadly effective antibiotic which inhibits RNA polymerase …

Background Due to the emergency of multidrug-resistant strains of Mycobacterium
tuberculosis, is necessary the evaluation of new compounds. Findings Tedizolid, a novel …

Tuberculosis is an infection caused by the rod-shaped, non–spore-forming, aerobic
bacterium Mycobacterium tuberculosis. Mycobacteria typically measure 0.5 ìm by 3 ìm, are …

The potent antimycobacterial activity of (±)-platencin is reported. Complete inhibition of
Mycobacterium smegmatis growth was observed at MICs of 0.5 μg mL− 1 and 0.3 μg mL− 1 …

Rationale Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity
against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models …

Objectives: The aim of this study was to identify a candidate drug for clinical development
from a previously synthesized combinatorial library based on the 1, 2-ethylenediamine …