Innate immunity responds to infections and inflammatory stimuli through a carefully
choreographed set of interactions between cells, stimuli and their specific receptors. Of …

The innate immune system utilizes many approaches for defense against invading
microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil …

LL-37, cleaved from human cathelicidin, and human neutrophil peptide-1 (HNP1) from the
defensin family are antimicrobial peptides that are occasionally co-released from …

LL-37 is the only cathelicidin produced by human cells. It is secreted by a variety of cell
types, including monocyte/macrophages, neutrophils, mast cells, keratinocytes and …

The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide)
expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under …

NETs (neutrophil extracellular traps) have been described as a fundamental innate immune
defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as …

Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin
LL-37 protects the epithelial barrier against infection and is constitutively secreted in the …

Cathelicidin LL-37 plays an essential role in innate immunity by killing invading
microorganisms and regulating the inflammatory response. These activities depend on the …

LL-37, the only member of the mammalian cathelicidin in humans, plays an essential role in
innate immunity by killing pathogens and regulating the inflammatory response. However, at …

Antimicrobial peptides produced by epithelial cells and neutrophils represent essential
elements of innate immunity, and include the defensin and cathelicidin family of …