Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the characteristics of these alterations, the …

Microcirculatory dysfunction has been recently recognized as a key pathophysiologic
process in the evolution of sepsis. In the present review, we discuss fundamental aspects of …

Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the various mechanisms that are potentially …

Sepsis is the number one cause of death among critically ill patients and accounts for more
than 215,000 deaths every year in the United States alone. 1, 2 Randomized controlled trials …

Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that
maintaining systemic blood pressure is associated with inadequate perfusion of the …

Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …

The microcirculation describes the smallest elements of the cardiovascular conducting
system and is pivotal in the maintenance of homeostasis. Microcirculatory dysfunction is …

Microcirculation plays an important role in the pathogenesis of shock and organ dysfunction,
especially in sepsis. Monitoring microcirculation at the bedside may be used to assess …

Microcirculation is a key element in the pathophysiology of sepsis. Even if microcirculation-
targeted therapy is not yet ready for the prime time, understanding the processes implicated …

This review examines experimental evidence that the microvascular dysfunction that occurs
early in sepsis is the critical first stage in tissue hypoxia and organ failure. A functional …