Pegylated G‐CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole‐body ionizing irradiation but not after …
JG Kiang, M Zhai, PJ Liao, DL Bolduc… - Oxidative medicine …, 2014 - Wiley Online Library
Exposure to ionizing radiation alone (radiation injury, RI) or combined with traumatic tissue
injury (radiation combined injury, CI) is a crucial life‐threatening factor in nuclear and …
injury (radiation combined injury, CI) is a crucial life‐threatening factor in nuclear and …
Combined therapy of pegylated G-CSF and Alxn4100TPO improves survival and mitigates acute radiation syndrome after whole-body ionizing irradiation alone and …
JG Kiang, M Zhai, DL Bolduc, JT Smith… - Radiation …, 2017 - meridian.allenpress.com
Exposure to ionizing radiation alone or combined with traumatic tissue injury is a crucial life-
threatening factor in nuclear and radiological incidents. Radiation injuries occur at the …
threatening factor in nuclear and radiological incidents. Radiation injuries occur at the …
PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the …
PA Plett, HL Chua, CH Sampson, BP Katz… - Health …, 2014 - journals.lww.com
Hematopoietic growth factors (HGF) are recommended therapy for high dose radiation
exposure, but unfavorable administration schedules requiring early and repeat dosing limit …
exposure, but unfavorable administration schedules requiring early and repeat dosing limit …
PEG-G-CSF and L-citrulline combination therapy for mitigating skin wound combined radiation injury in a mouse model
L Wang, M Zhai, B Lin, W Cui, L Hull, X Li… - Radiation …, 2021 - meridian.allenpress.com
Radiation combined injury (RCI, radiation exposure coupled with other forms of injury, such
as burn, wound, hemorrhage, blast, trauma and/or sepsis) comprises approximately 65% of …
as burn, wound, hemorrhage, blast, trauma and/or sepsis) comprises approximately 65% of …
Ghrelin therapy improves survival after whole‐body ionizing irradiation or combined with burn or wound: amelioration of leukocytopenia, thrombocytopenia …
JG Kiang, M Zhai, PJ Liao, TB Elliott… - … medicine and cellular …, 2014 - Wiley Online Library
Exposure to ionizing radiation alone (RI) or combined with traumatic tissue injury (CI) is a
crucial life‐threatening factor in nuclear and radiological events. In our laboratory, mice …
crucial life‐threatening factor in nuclear and radiological events. In our laboratory, mice …
Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation
TJ MacVittie, RL Monroy, ML Patchen… - International Journal of …, 1990 - Taylor & Francis
The short biologic half-life of the peripheral neutrophil (PMN) requires an active
granulopoietic response to replenish functional PMNs and to maintain a competent host …
granulopoietic response to replenish functional PMNs and to maintain a competent host …
Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole‐Body Ionizing Irradiation Followed by Wound …
JG Kiang, M Zhai, PJ Liao, C Ho… - Mediators of …, 2017 - Wiley Online Library
Ionizing radiation combined with trauma tissue injury (combined injury, CI) results in greater
mortality and H‐ARS than radiation alone (radiation injury, RI), which includes …
mortality and H‐ARS than radiation alone (radiation injury, RI), which includes …
Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation
The purpose of this study was to further elucidate the radioprotective role of granulocyte
colony-stimulating factor (G-CSF) induced in response to irradiation. The induction of G-CSF …
colony-stimulating factor (G-CSF) induced in response to irradiation. The induction of G-CSF …
[HTML][HTML] Preclinical development of a bridging therapy for radiation casualties
VK Singh, DS Brown, TC Kao, TM Seed - Experimental Hematology, 2010 - Elsevier
OBJECTIVE: Victims of a terrorist attack presenting with the hematopoietic syndrome
resulting from exposure to excessive levels of ionizing radiation will succumb to sepsis if not …
resulting from exposure to excessive levels of ionizing radiation will succumb to sepsis if not …
RhG-CSF improves radiation-induced myelosuppression and survival in the canine exposed to fission neutron irradiation
ZY Yu, M Li, S Xing, HL Ou, GL Xiong… - Journal of radiation …, 2011 - ieeexplore.ieee.org
Fission-neutron radiation damage is hard to treat due to its critical injuries to hematopoietic
and gastrointestinal systems, and so far few data are available on the therapeutic measures …
and gastrointestinal systems, and so far few data are available on the therapeutic measures …