Introduction Hexarelin exhibits significant protection against organ injury in models of
ischemia/reperfusion (I/R)-induced injury (IRI). Nevertheless, the impact of Hexarelin on …

Hexarelin, a synthetic hexapeptide, exerts cyto-protective effects at the mitochondrial level in
cardiac and skeletal muscles, both in vitro and in vivo, may also have important …

Hexarelin is a synthetic growth hormone-releasing peptide that exerts cardioprotective
effects. Regulation of autophagy is known to be cardioprotective so this study examined the …

Loss of cardiomyocytes by apoptosis is proposed to cause heart failure. Angiotensin II (ANG
II), an important neurohormonal factor during heart failure, can induce cardiomyocyte …

Background Previous evidence indicated that emodin has significant advantages for
preventing acute kidney injury (AKI). However, the mechanisms responsible for these effects …

Ferroptosis, as a novel regulable cell death, is characterized by iron overload, glutathione
depletion, and an accumulation of lipid peroxides. Recently, it has been discovered that …

Acute kidney injury (AKI) is a refractory clinical syndrome with limited effective treatments.
Amid AKI, activation of the extracellular signal-regulated kinase (ERK) cascade plays a …

Ischemia/reperfusion injury (IRI) is a major cause of acute kidney damage, which often
occurs in deceased donor kidney transplants. Cathelicidin PR-39 peptide possesses anti …

Acute myocardial ischemia and reperfusion injury (IRI) underly the detrimental effects of
coronary heart disease on the myocardium. Despite the ongoing advances in reperfusion …

Background: Acute kidney injury (AKI) is a common syndrome impacting about 13.3 million
patients per year. Tilianin has been reported to alleviate myocardial ischemia/reperfusion …