Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …

Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …

It has long been appreciated that cells contain microenvironments not enclosed by
membranes. In a classic study [1], Wilson concluded that the cytoplasm of star fish and sea …

Over a century ago, colloidal phase separation of matter into non-membranous bodies was
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …

In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular
activities in a spatially and temporally controlled manner. Numerous membraneless …

Eukaryotic cells are complex structures capable of coordinating numerous biochemical
reactions in space and time. Key to such coordination is the subdivision of intracellular …

Cells are exquisitely compartmentalized to achieve precise spatiotemporal regulation of
myriad processes and pathways. Phase separation offers one way to achieve territorial …

Liquid–liquid phase separation (LLPS) of biomolecules has emerged as an important
mechanism that contributes to cellular organization. Phase-separated biomolecular …

Membrane-less organelles are cellular structures which arise through the phenomenon of
phase separation. This process enables compartmentalization of specific sets of …

Cellular compartments and organelles organize biological matter. Most well-known
organelles are separated by a membrane boundary from their surrounding milieu. There are …