Cellular senescence mediates fibrotic pulmonary disease
MJ Schafer, TA White, K Iijima, AJ Haak… - Nature …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …
leading to compromised lung function. Cellular senescence markers are detectable within …
Cellular senescence in lung fibrosis
Fibrosing interstitial lung diseases (ILDs) are chronic and ultimately fatal age-related lung
diseases characterized by the progressive and irreversible accumulation of scar tissue in the …
diseases characterized by the progressive and irreversible accumulation of scar tissue in the …
Cellular senescence in idiopathic pulmonary fibrosis
DL Kellogg 3rd, DL Kellogg Jr, N Musi… - Current Molecular …, 2021 - Springer
Cellular senescence (CS) is increasingly implicated in the etiology of age-related diseases.
While CS can facilitate physiological processes such as tissue repair and wound healing …
While CS can facilitate physiological processes such as tissue repair and wound healing …
[HTML][HTML] Cell senescence and fibrotic lung diseases
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disorder with an unknown
etiology and very limited therapeutic options. The incidence and severity of IPF increase with …
etiology and very limited therapeutic options. The incidence and severity of IPF increase with …
Cellular senescence: pathogenic mechanisms in lung fibrosis
Pulmonary fibrosis is a chronic and fatal lung disease that significantly impacts the aging
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur… - …, 2019 - thelancet.com
Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease characterized by
progressive scarring of the lung tissue, leading to respiratory failure. There is no cure for IPF …
progressive scarring of the lung tissue, leading to respiratory failure. There is no cure for IPF …
Fibroblast senescence in idiopathic pulmonary fibrosis
Y Lin, Z Xu - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …
Cellular senescence and lung function during aging. Yin and Yang
J Campisi - Annals of the American Thoracic Society, 2016 - atsjournals.org
Cellular senescence is a cell fate decision and stress response that entails a permanent
arrest of cell proliferation coupled to a complex secretory phenotype. Senescent cells …
arrest of cell proliferation coupled to a complex secretory phenotype. Senescent cells …
Cellular senescence in aging lungs and diseases
A Aghali, ML Koloko Ngassie, CM Pabelick… - Cells, 2022 - mdpi.com
Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or
in response to exogenous stressors. Following the initial arrest, progressive phenotypic …
in response to exogenous stressors. Following the initial arrest, progressive phenotypic …