[HTML][HTML] An Enhanced Variant Designed From DLP4 Cationic Peptide Against Staphylococcus aureus CVCC 546

B Li, N Yang, X Wang, Y Hao, R Mao, Z Li… - Frontiers in …, 2020 - frontiersin.org
Insect defensins are promising candidates for the development of potent antimicrobials
against antibiotic-resistant Staphylococcus aureus (S. aureus). An insect defensin, DLP4 …

[HTML][HTML] Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus

Z Li, R Mao, D Teng, Y Hao, H Chen, X Wang… - Scientific reports, 2017 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis,
which urgently demanding new drugs for treating infection. Two homologous insect CSαβ …

[HTML][HTML] A novel peptide antibiotic, Pro10-1D, designed from insect defensin shows antibacterial and anti-inflammatory activities in sepsis models

M Krishnan, J Choi, A Jang, Y Kim - International journal of molecular …, 2020 - mdpi.com
Owing to the challenges faced by conventional therapeutics, novel peptide antibiotics
against multidrug-resistant (MDR) gram-negative bacteria need to be urgently developed …

Single deletion unmasks hidden anti-gram-negative bacterial activity of an insect defensin-derived peptide

B Gao, P Li, S Zhu - Journal of Medicinal Chemistry, 2024 - ACS Publications
Insect defensins are a large family of antimicrobial peptides primarily active against Gram-
positive bacteria. Here, we explore their hidden anti-Gram-negative bacterial potential via a …

Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide

H Saido-Sakanaka, J ISHIBASHI… - Biochemical …, 1999 - portlandpress.com
Defensin from a beetle, Allomyrina dichotoma, is known to have anti-bacterial activity
against Gram-positive bacteria. This peptide, which comprises 43 amino acid residues, was …

An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity

B Gao, S Zhu - ACS Chemical Biology, 2014 - ACS Publications
Insect defensins are a class of small, cysteine-rich antimicrobial peptides primarily active on
Gram-positive bacteria. Their roles in maggot therapy for treating chronic wound infection …

A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms

N Yang, D Teng, R Mao, Y Hao, X Wang… - Applied microbiology …, 2019 - Springer
There is an urgent need to discover new active drugs to combat methicillin-resistant
Staphylococcus aureus, which is a serious threat to humans and animals and incompletely …

Defensin‐like peptide3 from black solder fly: Identification, characterization, and key amino acids for anti‐Gram‐negative bacteria

SI Park, SM Yoe - Entomological research, 2017 - Wiley Online Library
An antibacterial peptide was isolated from a black soldier fly, Hermetia illucens. The
molecular mass of this peptide was established as 4247.37 by matrix‐assisted laser …

In vitro and in vivo activity of antimicrobial peptides synthesized based on the insect defensin

H Saido-Sakanaka, J Ishibashi, E Momotani, F Amano… - Peptides, 2004 - Elsevier
Synthetic antimicrobial 9-mer peptides were designed from the amino acid sequence of an
active site of insect defensin to increase the number of positively charged amino acid …

[HTML][HTML] Structure-activity relationships of insect defensins

J Koehbach - Frontiers in Chemistry, 2017 - frontiersin.org
Insects make up the largest and most diverse group of organisms on earth with several
million species to exist in total. Considering the sheer number of insect species and the vast …