The dynamics of oxygen delivery and utilization are examined in a variety of mitochondrial
disorders during rest, exercise and post exercise. We used a non-invasive optical technique …

Disorders of mitochondrial metabolism are manifest by inordinate fatigue, weakness, as well
as severe neuromuscular disorders. Diagnosis has required pathologic findings on muscle …

Patients with mitochondrial myopathies (MM) or myophosphorylase deficiency (McArdle's
disease, McA) show impaired capacity for O2 extraction, low maximal aerobic power, and …

Five patients with chronic progressive external ophthalmoplegia (CPEO) and 27 healthy
controls were examined by near-infrared spectroscopy (NIRS) for the noninvasive and direct …

We measured oxygen consumption in the exercising lower limb by using noninvasive tissue
oximetry with the near-infrared spectra of hemoglobin in the quadriceps muscle during …

Noninvasive measurement of changes in oxygenation of human skeletal muscle can be
done with a dual-wavelength near infrared (NIR) spectrophotometer. This allows a …

Oxygen debt is an old but as yet unresolved issue drawing debate that mitochondrial activity
can be initiated as rapidly as the initiation of work output. Recent NMR studies suggest it …

The purpose of this paper is to test whether peripheral oxygenation responses measured
with near-infrared spectroscopy (NIRS) would differ between patients suffering from …

Bioenergetic sufficiency can be quantitatively assayed by nuclear magnetic resonance
spectroscopy (MRS) and on a relative basis by tissue optical spectroscopy (NIRS). Nuclear …

Methods are described for the assessment of mitochondrial function in small (less than 50
mg) samples of human skeletal muscle using spectrophotometric assays to follow the …