We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Extensive studies have led to a variety of hypotheses for the molecular basis of depression
and related mood disorders, but a definite pathogenic mechanism has yet to be defined. The …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Recent studies have begun to characterize the actions of stress and antidepressant
treatments beyond the neurotransmitter and receptor level. This work has demonstrated that …

Since the 1960s, when the first tricyclic and monoamine oxidase inhibitor antidepressant
drugs were introduced, most of the ensuing agents were designed to target similar brain …

Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

Depression is a common and devastating neuropsychiatric disorder, and a better
understanding of its pathophysiology is needed to improve diagnosis, treatment and …

The underlying causes of most mood and anxiety disorders remain unknown. There is a
strong heritable component to psychiatric illnesses that, when coupled with environmental …