Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to
Alzheimer's disease (AD) development. Metabolic dysfunction and progressive neuronal …

Mitochondria contribute to shape intraneuronal Ca2+ signals. Excessive Ca2+ taken up by
mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca2+ overload …

Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Alzheimer's disease (AD) is the most common neurodegenerative disorder among the aged
worldwide. AD is characterized by extensive synaptic and neuronal loss that leads to …

Calcium signaling is essential for neuronal function, and its dysregulation has been
implicated across neurodegenerative diseases, including Alzheimer's disease (AD). A close …

Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD …

Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+
dyshomeostasis can lead to widespread impairment of cellular and synaptic signaling …

Age is the main risk factor for the onset of neurodegenerative diseases. A decline of
mitochondrial function has been observed in several age-dependent neurodegenerative …