Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

The ubiquitin proteasome system (UPS) plays a central role in cellular protein homeostasis
through the targeted destruction of damaged/misfolded proteins and regulatory proteins that …

The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular
physiology that tightly regulates cellular protein concentrations with specificity and precision …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

Proteins actively participate in a wide range of cellular physiological functions. But
aggregation of proteins results in cytotoxicity, and unwanted aggregation of misfolded …

The cancer drug discovery field has placed much emphasis on the identification of novel
and cancer-specific molecular targets. A rich source of such targets for the design of novel …

Abstract In May 2003, the US Food and Drug Administration granted the proteasome
inhibitor bortezomib (Velcade) fast-track status for the treatment of multiple myeloma. This …

Background: The ubiquitin–proteasome pathway functions as a main pathway in
intracellular protein degradation and plays a vital role in almost all cellular events. Various …

Background: The ubiquitin-proteasome system has become a promising novel molecular
target in cancer due to its critical role in cellular protein degradation, its interaction with cell …