Trigeminal nerve injury–induced neuropathic pain is a debilitating chronic orofacial pain
syndrome but lacks effective treatment. G protein–coupled receptors (GPCRs), especially …

Neuropathic pain is a major health problem that affects up to 7–10% of the population
worldwide. Currently, neuropathic pain is difficult to treat because of its elusive mechanisms …

G protein–coupled receptor 39 (GPR39) senses the change of extracellular divalent zinc ion
and signals through multiple G proteins to a broad spectrum of downstream effectors. Here …

The function of peripheral nociceptors is frequently tuned by the action of G protein-coupled
receptors (GPRs) that are expressed in them, which contribute to pain alteration. Expanding …

The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the
expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in …

GPR3 is an orphan G-protein coupled receptor broadly expressed in brain structures
controlling emotional-like behaviors and pain. GPR3 receptor up-regulates cAMP and …

G-protein receptor 84 (GPR84) is an orphan receptor that is induced markedly in monocytes/
macrophages and microglia during inflammation, but its pathophysiological function is …

Modulation of the function of somatosensory neurons is an important analgesic strategy,
requiring the proposal of novel molecular targets. Many G-protein-coupled receptors (GPRs) …

Neuropathic pain (NP) is mainly caused by lesions or diseases of the somatosensory
nervous system and triggers severe physical burdens to patients. It is claimed that activated …

G-protein-coupled receptors are considered to be cell-surface sensors of extracellular
signals, thereby having a crucial role in signal transduction and being the most fruitful …