Biomarkers are biological parameters that can be measured to, for example, demonstrate a
specific biological condition, diagnose a disease or monitor the effect of a therapeutic …

Using ProteinChip Technology (SELDI TOF MS), the maternal plasma of 53 chromosomally-
normal control and 28 Down's syndrome affected pregnancies was profiled between 10 and …

Objective: In this study, we aimed to search for noninvasive predictive biomarkers for
prenatal diagnosis of Down's syndrome (DS). Methods: Maternal serum samples from five …

Background 5% of first time pregnancies are complicated by pre-eclampsia, the leading
cause of maternal death in Europe. No clinically useful screening test exists; consequentially …

Preeclampsia, a hypertensive pregnancy complication, is largely unpredictable in healthy
nulliparous pregnant women. Accurate preeclampsia prediction in this population would …

Background To facilitate the experimental search for novel maternal serum biomarkers in
prenatal Down Syndrome screening, we aimed to create a set of candidate biomarkers …

Abstract Context: Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy that
substantially affects maternal and neonatal morbidity and mortality worldwide. The aetiology …

Objective In a previous discovery study, we identified seven potential screening markers for
Down syndrome (DS). Here, we report on an extended study to validate the discriminative …

1 in 20 first time pregnancies is complicated by pre-eclampsia, the leading cause of
maternal death in Europe. No clinically useful early pregnancy screening test exists …

Pre-eclampsia (PE) is a serious complication of pregnancy with potentially life threatening
consequences for both mother and baby. Presently there is no test with the required …