Injectable hydrogel with dual-sensitive behavior for targeted delivery of oncostatin M to improve cardiac restoration after myocardial infarction

Y Jiang, S Niu, Z Lin, L Li, P Yang, P Rao… - Journal of Materials …, 2022 - pubs.rsc.org
Myocardial infarction (MI) is a common cardiovascular disease that seriously endangers
human health and complex pathophysiology (eg, coronary artery obstruction, myocardial …

Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair

F Zhang, Y Zhang, S Qian, X Qian, J Jiao, B Ma… - ACS …, 2024 - ACS Publications
Substantial advancements have been achieved in the realm of cardiac tissue repair utilizing
functional hydrogel materials. Additionally, drug-loaded hydrogels have emerged as a …

An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction

Y Chen, J Shi, Y Zhang, J Miao, Z Zhao, X Jin… - Journal of Materials …, 2020 - pubs.rsc.org
Localized administration of anti-inflammatory agents benefits patients after myocardial
infarction (MI) by repressing/modulating inflammatory response of the MI region and thus …

Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis …

C Hu, W Liu, L Long, Z Wang, W Zhang, S He, L Lu… - Biomaterials, 2022 - Elsevier
Current treatments including drug therapy, medical device implantation, and organ
transplantation have considerable shortcomings for myocardial infarction (MI), such as high …

Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts

R Fang, S Qiao, Y Liu, Q Meng, X Chen… - International journal …, 2015 - Taylor & Francis
Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively
improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) …

A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury

S Liu, M Zhao, Y Zhou, L Li, C Wang, Y Yuan, L Li… - Acta biomaterialia, 2020 - Elsevier
Abstract Ischemia-reperfusion (I/R)-induced organ injury is a serious health problem
worldwide, and poor recovery of acute phase injury leads to chronic fibrosis and further …

An injectable ECM-like hydrogel with bioactive peptides and RepSox nanoparticles for myocardial infarction treatment

Z Wang, C Hu, W Zhang, W Liu, R Dong, S He… - Chemical Engineering …, 2023 - Elsevier
Injectable hydrogels have emerged as a promising strategy for the treatment of myocardial
infarction (MI) by delivering therapeutic cargo factors to modulate the infarct …

An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction

R Chen, C Zhu, L Xu, Y Gu, S Ren, H Bai, Q Zhou… - Biomaterials, 2021 - Elsevier
Drug-loaded hydrogels can improve blood supply and inhibit extracellular matrix
degradation after myocardial infarction. However, due to the continual dynamic motion of …

A Self-Association Cross-Linked conductive zwitterionic hydrogel as a myocardial patch for restoring cardiac function

X Hu, P Zhang, J Liu, H Guan, R Xie, L Cai… - Chemical engineering …, 2022 - Elsevier
In recent years, engineered cardiac patch (ECP) with electrical conductivity has been
developed for cardiac repair after injury or infarction. However, the application of traditional …

Advanced bioactive hydrogels for the treatment of myocardial infarction

Y Lu, Y Luo, R Zhu, X Huang, S Bai - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Myocardial infarction (MI) is the leading cause of cardiovascular disease-related deaths.
Local ischemia and cardiomyocyte death lead to a series of pathological remodeling events …