Mucociliary clearance and drug delivery via the respiratory tract

AB Lansley - Advanced drug delivery reviews, 1993 - Elsevier
Disruption of normal mucociliary clearance in the airways is undesirable due to the
associated risk of increased respiratory disease. Accordingly, pharmaceutical formulations …

Mucus and mucociliary clearance in the respiratory tract

C Marriott - Advanced drug delivery reviews, 1990 - Elsevier
Mucus is secreted within the respiratory tract down to the terminal bronchioles by the
combined activity of the epithelial goblet cells and submucosal mucous glands. These latter …

Nasal mucociliary clearance as a factor in nasal drug delivery

E Marttin, NGM Schipper, JC Verhoef… - Advanced drug delivery …, 1998 - Elsevier
The nasal mucociliary clearance system transports the mucus layer that covers the nasal
epithelium towards the nasopharynx by ciliary beating. Its function is to protect the …

The nasal mucociliary clearance: relevance to nasal drug delivery

NGM Schipper, JC Verhoef, FWHM Merkus - Pharmaceutical research, 1991 - Springer
Mucociliary clearance is an important physiological defense mechanism of the respiratory
tract to protect the body against noxious inhaled materials. This process is responsible for …

The effect of cilia and the mucociliary clearance on successful drug delivery

S Gizurarson - Biological and Pharmaceutical Bulletin, 2015 - jstage.jst.go.jp
Nasal mucociliary clearance is one of the most important factors affecting nasal delivery of
drugs and vaccines. This is also the most important physiological defense mechanism inside …

Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency

WM Boek, K Graamans, H Natzijl, PP van Rijk… - The …, 2002 - Wiley Online Library
Abstract Objectives/Hypothesis Mucociliary transport is an important defense mechanism of
the respiratory tract. Nonetheless, the factors determining mucociliary transport are only …

The assessment of nasal mucociliary clearance and the effect of drugs

C Rusznak, JL Devalia, S Lozewicz, RJ Davies - Respiratory medicine, 1994 - Elsevier
Mucociliary clearance provides an important protective function in the nose. A variety of
topically and systemically administered drugs are used to treat nasal pathologies and there …

Drug effects on mucociliary function.

D Pavia, PP Sutton, MT Lopez-Vidriero… - European Journal of …, 1983 - europepmc.org
We summarize the findings of 18 clinical studies carried out over a decade to ascertain the
effect of 14 pharmacological agents on lung mucociliary clearance. These studies were …

Effect of β-adrenergic agonists on mucociliary clearance

WD Bennett - Journal of Allergy and Clinical Immunology, 2002 - Elsevier
The mucociliary clearance apparatus, an important defense mechanism for clearing the lung
of bacteria and foreign particulate matter, is a well-coordinated system consisting of airway …

Effects of drugs on mucus clearance

E Houtmeyers, R Gosselink… - European …, 1999 - Eur Respiratory Soc
Mucociliary clearance (MCC), the process in which airway mucus together with substances
trapped within are moved out of the lungs, is an important defence mechanism of the human …