Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …

The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

Expression of mature messenger RNA s (mRNAs) requires appropriate transcription
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …

Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of
almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of …

Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …

Cleavage and polyadenylation is essential for 3′ end processing of almost all eukaryotic
mRNAs. Recent studies have shown widespread alternative cleavage and polyadenylation …

Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Regulation of gene expression by RNA processing mechanisms is now understood to be an
important level of control in mammalian cells. Regulation at the level of RNA transcription …