Alternative cleavage and polyadenylation: the long and short of it
B Tian, JL Manley - Trends in biochemical sciences, 2013 - cell.com
Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
Alternative cleavage and polyadenylation: extent, regulation and function
R Elkon, AP Ugalde, R Agami - Nature Reviews Genetics, 2013 - nature.com
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
Alternative polyadenylation of mRNA precursors
B Tian, JL Manley - Nature reviews Molecular cell biology, 2017 - nature.com
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors
AR Gruber, G Martin, W Keller… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Expression of mature messenger RNA s (mRNAs) requires appropriate transcription
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …
Signals for pre‐mRNA cleavage and polyadenylation
B Tian, JH Graber - Wiley interdisciplinary reviews: RNA, 2012 - Wiley Online Library
Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of
almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of …
almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of …
Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
M Hoque, Z Ji, D Zheng, W Luo, W Li, B You, JY Park… - Nature …, 2013 - nature.com
Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …
A compendium of conserved cleavage and polyadenylation events in mammalian genes
R Wang, D Zheng, G Yehia, B Tian - Genome research, 2018 - genome.cshlp.org
Cleavage and polyadenylation is essential for 3′ end processing of almost all eukaryotic
mRNAs. Recent studies have shown widespread alternative cleavage and polyadenylation …
mRNAs. Recent studies have shown widespread alternative cleavage and polyadenylation …
Alternative cleavage and polyadenylation in health and disease
AJ Gruber, M Zavolan - Nature Reviews Genetics, 2019 - nature.com
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Alternative polyadenylation: a twist on mRNA 3′ end formation
CS Lutz - ACS chemical biology, 2008 - ACS Publications
Regulation of gene expression by RNA processing mechanisms is now understood to be an
important level of control in mammalian cells. Regulation at the level of RNA transcription …
important level of control in mammalian cells. Regulation at the level of RNA transcription …