The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the
defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute …

The BCR-ABL1 fusion gene defines the subgroup of acute lymphoblastic leukemia (ALL)
with the worst clinical prognosis. To identify oncogenic lesions that combine with BCR-ABL1 …

Background Deletions of IKAROS (IKZF1) frequently occur in B-cell precursor acute
lymphoblastic leukemia (B-ALL) but the mechanisms by which they influence pathogenesis …

Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-
negative isoforms that interfere with its activity and correlate with poor prognosis in human …

Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid
lineages. The expression of short isoforms lacking DNA-binding motifs alters the …

The Ikaros transcription factor is crucial for many aspects of hematopoiesis. Loss of function
mutations in IKZF1, the gene encoding Ikaros, have been implicated in adult and pediatric B …

The timing and developmental sequence of events for BCR-ABL1+ acute lymphoblastic
leukemia (ALL), usually associated with IKAROS (IKZF1) deletions, are unknown. We …

PURPOSE: We sought to determine if molecular abnormalities involving the Ikaros gene
could contribute to the development of acute lymphoblastic leukemia (ALL) in children …

B cell lineage acute lymphoblastic leukemia (ALL) arises in virtually all cases from B cell
precursors that are arrested at pre–B cell receptor–dependent stages. The Philadelphia …

Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell
hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor …