Acetylcholine, the first neurotransmitter discovered, participates in many CNS functions,
including sensory and motor processing, sleep, nociception, mood, stress response …

Central nervous system cholinergic neurons arise from several discrete sources, project to
multiple brain regions, and exert specific effects on reward, learning, and memory. These …

Nicotine addiction is highly prevalent in current society and is often comorbid with other
diseases. In the central nervous system, nicotine acts as an agonist for nicotinic …

The cholinergic system plays important roles in both learning and addiction. Medications
that modify cholinergic tone can have pronounced effects on behaviors reinforced by natural …

Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

Drug addiction is a chronic neuropsychiatric disorder which is characterized by a
compulsion to take drugs and loss of control in limiting intake. The worldwide impact of drug …

Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate
in diverse functions: reward, learning and memory, mood, sensory processing, pain, and …

Nicotine is the principal addictive component that drives continued tobacco use despite
users' knowledge of the harmful consequences. The initiation of addiction involves the …

Nicotine addiction and other forms of drug addiction continue to be significant public health
problems in the United States and the rest of the world. Accumulated evidence indicates that …

Nicotine is the principle addictive agent delivered via cigarette smoking. The addictive
activity of nicotine is due to potent interactions with nicotinic acetylcholine receptors …