Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Allosteric modulation refers to the concept that proteins could exist in multiple
conformational states and that binding of allosteric ligands alters the energy barriers or …

The nicotinic acetylcholine receptor behaves as an allosteric protein with multiple,
interconvertible conformations: a resting state, an open channel state and several …

The study of nicotinic acetylcholine receptors (nAChRs) has significantly progressed in the
last decade, due to a) the improved techniques available for structural studies; b) the …

Ion channels expressed in the plasma membrane are broadly classified as voltage-gated
ion channels (VGICa) or ligand-gated ion channels (LGIC) where the ligand usually is …

Conventional nicotinic acetylcholine receptor (nAChR) agonists, such as acetylcholine, act
at an extracellular “orthosteric” binding site located at the interface between two adjacent …

Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of
agonists such as acetylcholine to an extracellular site that is located at the interface between …

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important
targets for drug discovery. The therapeutic potential of nicotinic agonists depends …

Similar to other neuroreceptors of the vertebrate central nervous system, the nicotinic
acetylcholine receptor (nAChR) is subject to modulatory control by allosterically acting …

Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …