Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

JY Han, JY Fan, Y Horie, S Miura, DH Cui… - Pharmacology & …, 2008 - Elsevier
Ischemia and reperfusion (I/R) exerts multiple insults in microcirculation, frequently
accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular …

Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats

Y Fei, S Wang, L Yang, Y Qiu, Y Li, W Liu, T Xi… - Journal of …, 2017 - Elsevier
Ethnopharmacological relevance Danshen is a crude herbal drug isolated from dried roots
of Salvia miltiorrhiza Bunge. This plant is widely used in oriental medicine for the treatment …

Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation

W Zhang, S Jun-Ke, X Zhang, Z Qi-Meng… - Chinese journal of …, 2018 - Elsevier
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza
Bge, a traditional Chinese medicine, which has been used for the treatment of …

Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-α

M Ding, TX Ye, GR Zhao, YJ Yuan, ZX Guo - International …, 2005 - Elsevier
Salvia miltiorrhiza Bunge, a traditional Chinese herbal medicine, is often used for prevention
and treatment of cardiovascular disorders such as atherosclerosis. To understand its …

Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages

H Liu, S Ma, H Xia, H Lou, F Zhu, L Sun - Journal of Ethnopharmacology, 2018 - Elsevier
Ethnopharmacological relevance The roots of Salvia miltiorrhiza f. alba (Lamiaceae)(RSMA)
are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at …

Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis

B Wei, C Sun, H Wan, Q Shou, B Han, M Sheng… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Salvia miltiorrhiza Bunge (SM) is an outstanding
herbal medicine with various traditional effects, especially promoting blood circulation to …

[HTML][HTML] Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

I Jung, H Kim, S Moon, H Lee, B Kim - Antioxidants, 2020 - mdpi.com
Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a medicinal herb that has been used for the
treatment for various diseases such as cardiovascular and cerebrovascular diseases in East …

Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction

K Chan, SH Chui, DYL Wong, WY Ha, CL Chan… - Life sciences, 2004 - Elsevier
Homocysteine (Hcy) is a by-product of methionine metabolism. An imbalance of Hcy in the
body may lead to hyperhomocysteinemia, a condition with elevated Hcy concentration in …

Crude extract of Salvia miltiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line

S Lay, JH Chiu, MS Shiao, WY Lui, CW Wu - Planta medica, 2003 - thieme-connect.com
Salvia miltiorrhiza (SM) has been used clinically in Asian countries to improve the
microcirculation in the human body. Although a pure compound extracted from SM …

Salvianolic acid C improves cerebral ischemia reperfusion injury through suppressing microglial cell M1 polarization and promoting cerebral angiogenesis

H Shen, H Pei, L Zhai, Q Guan, G Wang - International …, 2022 - Elsevier
This study aimed to investigate the mechanism of salvianolic acid C (SAC), the active
ingredient in Salvia miltiorrhiza, in improving cerebral ischemia injury. The mouse microglial …