Aims Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN)
protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy …

This study was to investigate whether sulforaphane (SFN) can prevent diabetic
cardiomyopathy. Type 1 diabetes was induced in FVB mice by multiple intraperitoneal …

Background NF-E2-related factor 2 (Nrf2) is a transcription factor playing cytoprotective
effects in various pathological processes including oxidative stress and cardiac hypertrophy …

Objective. This study investigated if resveratrol ameliorates diabetic cardiomyopathy by
targeting associated oxidative stress mechanisms. Method. Type 1 diabetes mellitus (DM) in …

To develop a clinic-relevant protocol for systemic up-regulation of NFE2-related factor 2
(Nrf2) to prevent diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type …

We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1
and type 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription …

Background AMP-activated protein kinase (AMPK), particularly AMPKα2 isoform, plays a
critical role in maintaining cardiac homeostasis. It was reported that sulforaphane (SFN) …

Diabetic cardiomyopathy and nephropathy are two major causes of death of patients with
diabetes. Extra generation of reactive oxygen species (ROS), induced by hyperglycemia, is …

OBJECTIVE Oxidative stress is implicated in cardiac insulin resistance, a critical risk factor
for cardiac failure, but the direct evidence remains missing. This study explored a causal link …

Sulforaphane (SFN) can effectively induce nuclear factor E2–related factor 2 (Nrf2), and zinc
(Zn) can effectively induce metallothionein (MT), both of which have been shown to protect …