Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Type III IFNs are important mediators of antiviral immunity. IFN-λ4 is a unique type III IFN
because it is produced only in individuals who carry a dG allele of a genetic variant …

Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …

Type III interferons (IFNs), also termed lambda IFNs (IFNλs) or interleukins-28/29, constitute
a new addition to the IFN family. They are induced upon infection and are particularly …

The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from
studies on animal models and cell lines. Virtually all pathogenic viruses have evolved …

Type III interferons (IFNs; IFN-λ) are antiviral cytokines with type I IFN-like biological
functions, including antiviral activity. In this article we review the literature on IFN-λ …