PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to
serve as a'rheostat'of the immune response. The molecular mechanisms of the functions of …

Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that
regulate the balance between T cell activation, tolerance, and immunopathology. Immune …

ABSTRACT PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells Mowing
activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative …

PD-1, an Ig superfamily member, contains an immunoreceptor tyrosine-based inhibitory
motif in the cytoplasmic tail. It is expressed in a minor fraction of CD4-CD8-normal …

Since the first observation of spontaneous autoimmune diseases in programmed cell death
1 (PD-1) knockout mice, PD-1 has been postulated to have essential roles in the regulation …

Abstract Programmed cell death 1 (PD-1) is an inducible immune modulatory receptor. Upon
interaction with its ligands B7 homolog 1 (PD-L1) and B7-DC (PD-L2), PD-1 plays important …

PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells,
and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Δex2 …

PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the
PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The …

T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …

PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and
contains two tyrosine residues in the cytoplasmic region. Studies on PD-1-deficient mice …