Differentiated thyroid carcinomas (DTCs), which have papillary and follicular types, are
common endocrine malignancies worldwide. Cancer stem cells (CSCs) are a particular type …

Background Disulfiram (DSF) is a drug used for treatment of alcoholism that has also
displayed promising anti-cancer activity. It unfolds its effects by inhibiting the enzyme activity …

Background Tumor resistance is a global challenge for tumor treatment. Cancer stem cells
(CSCs) are the main population of tumor cells for drug resistance. We have reported that …

BRAFV600E, the most common genetic alteration, has become a major therapeutic target in
thyroid cancer. Vemurafenib (PLX4032), a specific inhibitor of BRAFV600E kinase, exhibits …

Late‐stage hepatocellular carcinoma (HCC) usually has a low survival rate because of the
high risk of metastases and the lack of an effective cure. Disulfiram (DSF) has copper (Cu) …

Background: Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer
stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram …

Cancer is a major global health issue. Effective therapeutic strategies can prolong patients'
survival and reduce the costs of treatment. Drug repurposing, which identifies new …

In the presence of copper (Cu), disulfiram (DSF) suppresses properties associated with
cancer stem cells (CSCs) in breast cancer, but the mechanism of action is poorly …

The disulfiram/copper complex (DS/Cu) has been demonstrated to exert potent anti-tumor
effects in various types of cancer. At present, whether DS/Cu has chemopreventive effects …

Disulfiram/copper (DSF/Cu) is a promising antitumor reagent for clinical application due to
its excellent anticancer activity and safety. However, the anticancer mechanism of DSF/Cu …