Long‐term oral resveratrol intake provides nutritional preconditioning against myocardial ischemia/reperfusion injury: Involvement of VDAC1 downregulation

Z Liao, D Liu, L Tang, D Yin, S Yin, S Lai… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope This study elucidates the effects of long‐term nutritional preconditioning by
resveratrol on ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods and …

Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 β pathway

M Tian, Y Xie, Y Meng, W Ma, Z Tong, X Yang… - European journal of …, 2019 - Elsevier
Our previous studies showed that the effect of resveratrol preventing mitochondrial
permeability transition pore (mPTP) opening in myocardial ischemia/reperfusion injury was …

Coordinated induction of iNOS–VEGF–KDR–eNOS after resveratrol consumption: A potential mechanism for resveratrol preconditioning of the heart

S Das, VKT Alagappan, D Bagchi, HS Sharma… - Vascular …, 2005 - Elsevier
Existing evidence indicates that resveratrol, a red wine and grape-derived polyphenolic
antioxidant, can pharmacologically precondition the heart in a nitric oxide (NO)-dependent …

Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3β and mitochondrial permeability transition pore

J Xi, H Wang, RA Mueller, EA Norfleet, Z Xu - European journal of …, 2009 - Elsevier
Resveratrol pretreatment can protect the heart by inducing pharmacological preconditioning.
Whether resveratrol protects the heart when applied at reperfusion remains unknown. We …

A Meta‐Analysis of Resveratrol Protects against Myocardial Ischemia/Reperfusion Injury: Evidence from Small Animal Studies and Insight into Molecular Mechanisms

ZJ Mao, H Lin, JW Hou, Q Zhou… - … Medicine and Cellular …, 2019 - Wiley Online Library
Aims. Myocardial ischemia/reperfusion (I/R) injury is a leading cause of cardiomyocyte loss
and subsequent ventricular dysfunction after restoring the coronary blood flow and …

Resveratrol, novel application by preconditioning to attenuate myocardial ischemia/reperfusion injury in mice through regulate AMPK pathway and autophagy level

H Li, F Zheng, Y Zhang, J Sun, F Gao… - Journal of Cellular and …, 2022 - Wiley Online Library
Myocardial ischemia/reperfusion injury (MI/RI) is the main cause of deaths in the worldwide,
leading to severe cardiac dysfunction. Resveratrol (RSV) is a polyphenol plant‐derived …

The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms

SSC Goh, OL Woodman, S Pepe, AH Cao… - Antioxidants & redox …, 2007 - liebertpub.com
The objective was a comprehensive investigation of the mechanisms and sites of resveratrol
cardioprotection during and following ischemia–reperfusion (I–R) injury, and to determine …

Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cells

X Wu, S Zhou, N Zhu, X Wang… - Molecular …, 2014 - spandidos-publications.com
Resveratrol is able to protect myocardial cells from ischemia/reperfusion‑induced injury.
However, the mechanism has yet to be fully elucidated. In the present study, it is reported …

VDAC1 deacetylation is involved in the protective effects of resveratrol against mitochondria-mediated apoptosis in cardiomyocytes subjected to anoxia/reoxygenation …

Z Tong, Y Xie, M He, W Ma, Y Zhou, S Lai… - Biomedicine & …, 2017 - Elsevier
We have recently demonstrated that Voltage-dependent anion channel 1 (VDAC1), a protein
located in the mitochondrial outer membrane, is involved in the effects of resveratrol on the …

Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation

S Das, GA Cordis, N Maulik… - American Journal of …, 2005 - journals.physiology.org
Recent studies demonstrated that resveratrol, a grape-derived polyphenolic phytoalexin,
provides pharmacological preconditioning (PC) of the heart through a NO-dependent …